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Objective To explore the distribution and disease characteristics of influenza virus A in severe pneumonia cases in Nanchang city, so as to provide evidence for clinical prevention and treatment of severe pneumonia cases. Methods The respiratory samples and clinical case data of severe pneumonia cases were collected and the etiology and epidemiology were analyzed in Nanchang from April 2013 to March 2018. Results From April 2013 to March 2018, 261 case patients of severe pneumonia from 17 medical institutions in Nanchang were enrolled. 77 cases was detected as positive for influenza A virus nucleic acid, accounting for 29.50% of the total cases, as follow: 39 cases of A (H1N1pdm) influenza, 13 A (H3), 16 H7N9 and 3 H10N8 avian influenza. Cases were mainly concentrated in winter and spring (from December to May of next year, with median age 48 of years, including 48 males and 31 females. 21 cases of human infection with H7N9/H10N8 avian influenza were reported in Nanchang during 5 years, with the fatality rate of 33.33%. 90.48% (19/21) cases were detected by unexplained pneumonia surveillance system. The median age was 69 years, most of them had underlying diseases and a clear history of poultry contact. Conclusions Nearly 30% of the severe pneumonia cases in Nanchang city were infected with influenza A virus, among which influenza A (H1N1pdm) virus was the main epidemic strain. All deaths were caused by avian influenza virus infection.
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Objective To explore the distribution and disease characteristics of influenza virus A in severe pneumonia cases in Nanchang city, so as to provide evidence for clinical prevention and treatment of severe pneumonia cases. Methods The respiratory samples and clinical case data of severe pneumonia cases were collected and the etiology and epidemiology were analyzed in Nanchang from April 2013 to March 2018. Results From April 2013 to March 2018, 261 case patients of severe pneumonia from 17 medical institutions in Nanchang were enrolled. 77 cases was detected as positive for influenza A virus nucleic acid, accounting for 29.50% of the total cases, as follow: 39 cases of A (H1N1pdm) influenza, 13 A (H3), 16 H7N9 and 3 H10N8 avian influenza. Cases were mainly concentrated in winter and spring (from December to May of next year, with median age 48 of years, including 48 males and 31 females. 21 cases of human infection with H7N9/H10N8 avian influenza were reported in Nanchang during 5 years, with the fatality rate of 33.33%. 90.48% (19/21) cases were detected by unexplained pneumonia surveillance system. The median age was 69 years, most of them had underlying diseases and a clear history of poultry contact. Conclusions Nearly 30% of the severe pneumonia cases in Nanchang city were infected with influenza A virus, among which influenza A (H1N1pdm) virus was the main epidemic strain. All deaths were caused by avian influenza virus infection.
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Objective :To study application value of serum sCD40L and NT‐proBNP levels detection in early diagnosis and prognosis assessment of aged patients with heart failure (HF).Methods :A total of 73 aged HF patients treated in our hospital from Feb 2015 to Feb 2017 were selected as HF group .According to NYHA cardiac function class , HF group was divided into class Ⅱ group (n＝37) and class Ⅲ group (n＝36).A total of 112 healthy people ,who had a physical examination in our hospital at the corresponding period ,were selected as health group .HF group were treated for one month .Incidence of major adverse cardiovascular events (MACE) within one‐month was re‐corded .According to MACE during one‐month follow‐up ,HF group was divided into MACE group (n＝20) and no MACE group (n＝53).Serum levels of sCD40L and NT‐proBNP were measured and compared between HF group before treatment and health group ;class Ⅱ group and class Ⅲ group before and after treatment ;MACE group and no MACE group .Results :There were significant rise in serum levels of sCD 40L and NT‐proBNP in HF group be‐fore treatment compared with health group , P＝0. 001 all.Compared with before treatment ,there were significant reductions in serum levels of sCD40L and NT‐proBNP in class Ⅱ group and class Ⅲ group , P＝ 0.001 all.After treatment ,compared with class Ⅲ group there was significant reduction in serum level of sCD40L [ (8.31 ± 0.76) ng／ml vs .(7.37 ± 0.81) ng／ml] in class Ⅱ group , P＝0. 001. During one‐month follow‐up ,20 cases of MACE oc‐curred in HF group (n＝73) and incidence of MACE in HF group was 27.40% .Compared with MACE group ,there were significant reductions in serum levels of sCD 40L [ (10.26 ± 1.54) ng／ml vs.(11. 49 ± 1. 81) ng／ml] and NT‐proBNP [(612. 28 ± 122. 76) ng／L vs.(1072.25 ± 245.68) ng／L] in no MACE group ,P＝0. 001 all.Conclusion :Se‐rum sCD40L and NT‐proBNP levels detection possesses good application value in early diagnosis and prognosis assess‐ment for aged patients with HF ,which is worth extending .
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<p><b>OBJECTIVE</b>To explore the relationship between metabolic syndrome and chronic kidney disease (CKD) in a rural adult population of Hunan province.</p><p><b>METHODS</b>1953 residents (older than 18 years) from the same village were randomly selected, using a stratified, multistage sampling method. All residents were interviewed and tested for albuminuria with morning spot urine albumin to creatinine ratio (abnormal: >/= 30 mg/g), reduced renal function with estimated glomerular filtration rate by modified MDRD equation [abnormal: < 60 ml/min (1.73 m(2))]. The associations of kidney damage indicators with demographic characteristics (age, gender, smoking status), indicators on health (diabetes, hypertension) and metabolic syndrome traits were examined.</p><p><b>RESULTS</b>Eligible data of 1709 subjects were enrolled in the study. After the adjustment of age, gender and other metabolic syndrome traits, participants with metabolic syndrome had a higher prevalence of CKD (19.3% vs. 13.2%, P < 0.001) than those without the syndrome. As the number of metabolic syndrome traits increased, so did the prevalence of CKD. There seemed to be a strong and independent association between metabolic syndrome and chronic kidney disease. For participants without hypertension and diabetes, metabolic syndrome was also associated with CKD (OR value 1.733, 95%CI: 1.20 - 2.41, P = 0.004).</p><p><b>CONCLUSION</b>In these 1709 adults under this study from a village of southern China, metabolic syndrome seemed to be associated with CKD.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , China , Epidemiology , Diabetes Mellitus , Epidemiology , Hypertension , Epidemiology , Metabolic Syndrome , Epidemiology , Prevalence , Renal Insufficiency, Chronic , Epidemiology , Risk Factors , Rural PopulationABSTRACT
<p><b>AIM</b>To study the expression pattern of the retinoic acid metabolizing enzymes RALDH2 and CYP26b1 during mouse postnatal testis development at both mRNA and protein levels.</p><p><b>METHODS</b>Real-time polymerase chain reaction and Western blot analysis were performed to determine the relative quantity of RALDH2 and CYP26b1 at both mRNA and protein levels at postnatal day 1, 5, 10, 20, and in adult mice (70 days testes). Testicular localization of RALDH2 and CYP26b1 during mouse postnatal development was examined using immunohistochemistry assay.</p><p><b>RESULTS</b>Aldh1a2 transcripts and its protein RALDH2 began to increase at postnatal day 10, and remained at a high level through postnatal day 20 to adulthood. Cyp26b1 transcripts and CYP26b1 protein did not change significantly during mouse postnatal testis development. RALDH2 was undetectable in the postnatal 1, 5 and 10 day testes using immunohistochemistry assay. At postnatal day 20 it was detected in pachytene spermatocytes. Robust expression of RALDH2 was restricted in round spermatids in the adult mouse testis. In the developing and adult testis, CYP26b1 protein was confined to the peritubular myoepithelial cells.</p><p><b>CONCLUSION</b>Our results indicate that following birth, the level of retinoic acid in the seminiferous tubules might begin to increase at postnatal day 10, and maintain a high level through postnatal day 20 to adulthood.</p>